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48 Elm Street, Suite 3 | Worcester, MA 01609

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Pancreatic Cancer

Learn About
Pancreatic Cancer

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Pancreatic Cancer and Gum Disease

Pancreatic cancer is the fourth leading cause of cancer deaths in the U.S.; more than 30,000 Americans are expected to die from the disease this year. It is an extremely difficult cancer to treat, and little is known about what causes it. One established risk factor in pancreatic cancer is cigarette smoking; other links have been made to obesity, diabetes type 2, and insulin resistance. In a new study, researchers at the Harvard School of Public Health (HSPH) and Dana-Farber Cancer Institute found that periodontal disease was associated with an increased risk of cancer of the pancreas. The study appeared in the January 17, 2007, issue of the Journal of the National Cancer Institute.

“Our study provides the first strong evidence that periodontal disease may increase the risk of pancreatic cancer. This finding is of significance as it may provide some new insights into the mechanism of this highly fatal disease,” said lead author Dominique Michaud, assistant professor of epidemiology at HSPH.

Periodontal disease is caused by bacterial infection and inflammation of the gums that, over time, cause loss of bone supporting the teeth; tooth loss is a consequence of severe periodontal disease. Two previous studies had found a link between tooth loss or periodontitis and pancreatic cancer. One study consisted of all smokers, and the other did not control for smoking in the analysis; therefore, no firm conclusions could be drawn from these studies.

Data for the new study came from the Health Professionals Follow-Up Study, which began in 1986, and included 51,529 U.S. men working in the health professions. Participants responded to questionnaires about their health every two years. After analyzing the data, the researchers confirmed 216 cases of pancreatic cancer between 1986 and 2002; of those, 67 reported periodontal disease.

The results showed that–after adjusting for age, smoking, diabetes, body mass index, and a number of other factors–men with periodontal disease had a 63% higher risk of developing pancreatic cancer compared to those reporting no periodontal disease. “Most convincing was our finding that never-smokers had a two-fold increase in risk of pancreatic cancer,” said Michaud.

One possible explanation for the results is that inflammation from periodontal disease may promote cancer of the pancreas. “Individuals with periodontal disease have elevated serum biomarkers of systemic inflammation, such as C-reactive protein, and these may somehow contribute to the promotion of cancer cells,” she said.

Another explanation, according to Michaud, is that periodontal disease could lead to increased pancreatic carcinogenesis because individuals with periodontal disease have higher levels of oral bacteria and higher levels of nitrosamines, which are carcinogens, in their oral cavity. Prior studies have shown that nitrosamines and gastric acidity may play a role in pancreatic cancer.

Michaud; senior author Charles Fuchs, a gastrointestinal oncologist at Dana-Farber; and their colleagues believe that further studies should be done to investigate the role of inflammation from periodontal disease in pancreatic cancer. However, Michaud notes that the underlying mechanisms for this association are speculative at this point. “More research is needed both to confirm this finding in other populations and also to explore the role of inflammation in this particular cancer,” she said.

To schedule a consultation or learn more about gum disease, please contact us at our Worcester, MA office today!

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Location

48 Elm Street, Suite 3
Worcester, MA 01609

Hours

Monday - Friday
8:00AM - 5PM

Directions

Our Office is conveniently
located in Worcester, MA.

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Here at Worcester Periodontics, we work diligently to protect our patient's rights and privacy. Requesting an appointment via our Internet portal is considered part of what HIPAA has identified as electronically protected information (ePHI). Unfortunately, despite the best efforts we make or take, there are people or entities that may attempt to intercept the data you transmit to us. By checking the box, and electronically making an appointment, you understand that you are making an appointment over the internet and that Worcester Periodontics will keep this information confidential but cannot guarantee that others, outside of our practice, may not illegally intercept this communication. As a result of continuing, you are sending this transmission and accepting the inherent risk(s) associated with making this request for an appointment. As an alternative, you are always welcome to contact our office via telephone to schedule your appointment.

Disclaimer

The information presented here is not intended or implied to be medical advice, diagnosis, or treatment. It should be used for informational purposes only.

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